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KMID : 0369819960260010023
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Jorunal of Korean Pharmaceutical Sciences
1996 Volume.26 No. 1 p.23 ~ p.28
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Enhancement of Dissolution Properties through Formulations of Insoluble Drug Biphenyl Dimethyl Dicarboxylate
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이순아/Lee SA
송경/박은전/손동환/고건일/김재백/Song K/Park EJ/Sohn DH/Go GI/Kim JB
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Abstract
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The dissolution characteristics of DDB were markedly enhanced by preparing solid dispersions of drug with polyethylene glycol 6000. Solid dispersions of various weight fraction were formed by a melting method. And various tablets(A∼E) were prepared from these solid dispersions with excipients (lactose, com starch, Avicel and PVP) by wet granulation method. There were no significant differences in dissolution rates between physical mixture and DDB alone. But dissolution rates of solid dispersions were 1.4∼2.0 times greater than that of DDB alone and 1.2∼1.8 times greater than those of a commercial tablet.
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KEYWORD
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Biphenyl dimethyl dicarboxylate(DDB), Solid dispersions, Dissolution rates, Physical mixture
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